Objective To construct an intradialytic exercise intervention program for maintenance hemodialysis （MHD） patients with sarcopenia,and to evaluate its effects. Methods We constructed an intradialytic exercise intervention program for MHD patients with sarcopenia based on evidence summary and Delphi method. 51 patients with sarcopenia who underwent hemodialysis in a tertiary hospital in Lianyungang from March to July 2021 were randomly divided into an experimental group（25 cases） and a control group（26 cases）. The experimental group was given the intradialytic exercise intervention program on the basis of routine nursing. The intradialytic exercise intervention program in MHD patients with sarcopenia includes 5 parts,including pre-exercise assessment,exercise prescription,exercise monitoring,exercise-related support,and exercise effect evaluation. While the control group was given routine nursing during dialysis. After the intervention,the differences in the prevalence of sarcopenia,skeletal muscle mass index,mid-arm muscle circumference,calf circumference,grip strength,usual gait speed and the short physical performance battery（SPPB） score between the 2 groups were compared to evaluate effects of the intervention. Results The prevalence of sarcopenia in the experimental group was lower than that in the control group（P=0.014）,and the grip strength,usual gait speed,calf circumference and the SPPB score were higher than those in the control group after the intervention（P<0.05）. Conclusion The intradialytic exercise intervention program for MHD patients with sarcopenia is scientific and reliable,and the application of this program can effectively improve the relevant indicators of sarcopenia and decrease the prevalence of sarcopenia,which can provide a reference for clinical nursing practice.